Our laboratory is studying the molecular basis of human antibody responses to diseases. Antibodies are key components of most licensed vaccines; nevertheless, many aspects of how antibodies recognize and neutralize their targets are still unknown. Pathogen-specific B cells are stimulated after antigen encounter and subsequently undergo affinity maturation and selection in distinct anatomical structures called germinal centers. After several rounds of affinity maturation and selection, some B cell clones acquire a high affinity for the antigen, and sometimes the ability to neutralize it.
To characterize the human responses to diseases we use single B cell methods and isolate the antibodies from patients at different disease stages. We focus on the human antibody responses towards infectious diseases such as HIV-1, Tuberculosis and SARS CoV-2, as well as B cell responses during cancer and under stress. Our ultimate goal is to exploit our knowledge of the human antibody responses for the development of new diagnostic tools, immune-treatments and for the discovery of new vaccine targets.
The Freund Lab is aspiring to foster a creative and free academic environment that nurtures young scientists from diverse backgrounds.
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We are currently hiring! We are looking for talented and open minded people to join our growing team.
We have open positions for rotation, MSc and PhD students.
Sackler Faculty of Medicine, Room 801-802
Department of Clinical Microbiology and Immunology
Tel Aviv University, Tel Aviv 69978, Israel